产品货号：
GS4875
中文名称：
重组人IL-15
英文名称：
Recombinant Human Interleukin-15
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 12.9kDa,a single non-glycosylated polypeptide chain containing 114 amino acids.
储存条件：冷冻（-20℃）
概述
Human Interleukin-15(IL-15)is expressed by the IL15 gene located on the chromosome 4.It shares approximately 97%and 73%sequence identity with simian and murine IL-15,respectively.Both human IL-15 and simian IL-15 are active on murine cells.IL-15 is secreted by mononuclear phagocytes(and some other cells),especially macrophages following infection by virus.It possesses a variety of biological functions,including stimulating and maintaining of cellular immune responses,especially regulating T and natural killer(NK)cell activation and proliferation.In additionally,it shares many biological properties with IL-2,including T,B and NK cell-stimulatory activities.IL-15 signals through a complex composed of IL-2/IL-15 receptor beta chain.Although IL-15 lacks sequence homology with IL-2,it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling.In addition,an IL-15 specific binding protein has also been cloned from a mouse T cell clone.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人IL-15，IL-15, Human，Recombinant Human Interleukin-15
储存条件：冷冻（-20℃）
概述
Human Interleukin-15(IL-15)is expressed by the IL15 gene located on the chromosome 4.It shares approximately 97%and 73%sequence identity with simian and murine IL-15,respectively.Both human IL-15 and simian IL-15 are active on murine cells.IL-15 is secreted by mononuclear phagocytes(and some other cells),especially macrophages following infection by virus.It possesses a variety of biological functions,including stimulating and maintaining of cellular immune responses,especially regulating T and natural killer(NK)cell activation and proliferation.In additionally,it shares many biological properties with IL-2,including T,B and NK cell-stimulatory activities.IL-15 signals through a complex composed of IL-2/IL-15 receptor beta chain.Although IL-15 lacks sequence homology with IL-2,it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling.In addition,an IL-15 specific binding protein has also been cloned from a mouse T cell clone.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1EU/μg of rHuIL-15 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS |
相关搜索：重组人IL-15，IL-15, Human，Recombinant Human Interleukin-15